James H McKerrow Selected Research

Parasitic Diseases (Parasitic Disease)

12/2017	4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
1/2017	Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent.
1/2017	The rule of five should not impede anti-parasitic drug development.
4/2015	Protease inhibitors targeting coronavirus and filovirus entry.
4/2014	R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.
7/2013	Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].
5/2011	Mining a cathepsin inhibitor library for new antiparasitic drug leads.
1/2011	The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion.
10/2010	Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology.
9/2010	In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

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James H McKerrow Research Topics

Disease

27	Infections 05/2021 - 04/2002
26	Chagas Disease (American Trypanosomiasis) 01/2020 - 11/2007
17	Parasitic Diseases (Parasitic Disease) 12/2017 - 01/2005
9	Schistosomiasis (Bilharziasis) 07/2017 - 04/2005
6	Neglected Diseases 03/2020 - 12/2006
6	African Trypanosomiasis (Nagana) 05/2015 - 03/2002
5	COVID-19 01/2022 - 10/2020
5	Malaria 05/2011 - 01/2005
4	Rheumatoid Arthritis 01/2017 - 05/2007
4	Amebiasis (Amoebiasis) 05/2016 - 01/2002
4	Neoplasms (Cancer) 01/2016 - 05/2007
3	Cysts 01/2020 - 06/2008
3	Leishmaniasis 04/2013 - 10/2008
3	Schistosomiasis mansoni 01/2012 - 09/2004
2	Acanthamoeba Keratitis 11/2021 - 01/2020
2	Disease Progression 01/2020 - 09/2008
2	Protozoan Infections 01/2018 - 12/2008
2	Toxoplasmosis 01/2018 - 12/2008
2	Cryptosporidiosis 12/2013 - 12/2008
2	Amebic Dysentery (Amoebic Dysentery) 06/2012 - 07/2007
2	Mycoses (Diseases, Fungus) 06/2010 - 04/2010
2	Osteoporosis 12/2008 - 05/2007
2	Acquired Immunodeficiency Syndrome (AIDS) 12/2008 - 12/2005
1	Alcoholism (Alcohol Abuse) 06/2022
1	Vector Borne Diseases 10/2021
1	Acute Disease 01/2020
1	Central Nervous System Protozoal Infections (Meningoencephalitis, Protozoal) 01/2018
1	Meningoencephalitis 12/2017
1	Parasitemia 12/2017
1	Alzheimer Disease (Alzheimer's Disease) 07/2017
1	Asthma (Bronchial Asthma) 07/2017
1	Chronic Obstructive Pulmonary Disease (COPD) 07/2017
1	Coronavirus Infections 04/2015
1	Chronic Pancreatitis 04/2015
1	Visceral Leishmaniasis (Kala Azar) 03/2015
1	Onchocerciasis 02/2015
1	Filarial Elephantiasis (Lymphatic Filariasis) 02/2015
1	Keratitis 01/2014

Drug/Important Bio-Agent (IBA)

34	Pharmaceutical PreparationsIBA 01/2022 - 05/2006
18	Cysteine Proteases (Cysteine Protease)IBA 01/2020 - 01/2002
15	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 01/2005
11	cruzipainIBA 01/2020 - 11/2007
7	EnzymesIBA 12/2017 - 12/2008
6	Cysteine Proteinase InhibitorsIBA 01/2021 - 01/2007
6	SterolsIBA 01/2020 - 01/2009
6	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2005
5	benzonidazole (benznidazole)IBA 03/2020 - 11/2007
5	Auranofin (Ridaura)FDA Link 01/2017 - 06/2012
4	Cathepsin LIBA 01/2022 - 12/2012
4	AzolesIBA 11/2021 - 04/2010
4	N- pip- phenylalanine- homophenylalanine- vinyl sulfone phenylIBA 01/2018 - 01/2007
4	PapainIBA 12/2012 - 04/2002
3	GoldIBA 01/2017 - 02/2015
3	14-alpha Demethylase InhibitorsIBA 03/2015 - 06/2010
3	Protease Inhibitors (Protease Inhibitor)IBA 11/2012 - 11/2007
3	SerpinsIBA 01/2012 - 09/2007
2	Antiviral Agents (Antivirals)IBA 01/2022 - 12/2020
2	gallinamide AIBA 01/2022 - 12/2020
2	ProteomeIBA 01/2020 - 07/2008
2	posaconazole FDA Link 01/2020 - 06/2010
2	Phosphotransferases (Kinase)IBA 01/2020 - 07/2013
2	CathepsinsIBA 01/2018 - 05/2011
2	divinyl sulfoneIBA 01/2018 - 01/2007
2	NifurtimoxIBA 12/2017 - 11/2007
2	Cathepsin BIBA 12/2014 - 09/2008
2	corifunginIBA 01/2014 - 11/2012
2	Biological ProductsIBA 04/2013 - 09/2011
2	AntigensIBA 03/2009 - 09/2007
2	falcipain 2IBA 08/2006 - 01/2005
2	VaccinesIBA 12/2005 - 08/2004
1	DisulfidesIBA 06/2022
1	Disulfiram (Antabuse)FDA Link 06/2022
1	Thiram FDA Link 06/2022
1	Anti-Infective Agents (Microbicides)IBA 11/2021
1	Antifungal AgentsIBA 11/2021
1	Pentamidine (NebuPent)FDA LinkGeneric 11/2021
1	BiguanidesIBA 11/2021
1	Z-200 (Z 200)IBA 05/2021
1	propamidine isethionateIBA 01/2020
1	chlorhexidine gluconate (Dyna-Hex)FDA LinkGeneric 01/2020
1	isavuconazoleIBA 01/2020
1	Sterol 14-DemethylaseIBA 01/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2020
1	polihexanideIBA 01/2020
1	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2018
1	miltefosine (Impavido)IBA 01/2018
1	Cyclic NucleotidesIBA 07/2017
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 07/2017
1	MMV001239IBA 01/2017
1	benzamideIBA 01/2017
1	ThiophenesIBA 01/2016
1	benzimidazoleIBA 01/2016
1	Cytochromes b (Cytochrome b)IBA 07/2015
1	rhodesainIBA 05/2015
1	camostatIBA 04/2015
1	Serine (L-Serine)FDA Link 04/2015
1	Ergosterol (Lumisterol)IBA 04/2014

Therapy/Procedure

13	Drug Therapy (Chemotherapy) 01/2015 - 03/2002
5	Therapeutics 12/2017 - 04/2005
1	Blood Transfusion (Blood Transfusions) 10/2021